Endocrine Abstracts

Androgen excess in post-menopausal women usually results from ovarian or adrenal pathology. Identifying pathology is significant as many ovarian tumors can be malignant in nature. We report a case of granulosa cell tumor which presented with virilizing signs. A 66-year-old postmenopausal lady presented with temporal hair loss and weight gain. She had to drop out of her church choir as she had a change in her voice. She was concerned about her facial hair growth which was signi...

Introduction: Bisphosphonates are widely used to treat osteoporosis, hypercalcemia of malignancy and multiple myeloma. Albeit rare, bisphosphonate induced osteonecrosis of jaw is serious adverse event which significantly affects quality of life. Clinical presentation includes gingival ulceration, exposed necrotic bone in the oral cavity. In severe cases it may cause spontaneous pain, tooth mobility and pathological fractures.Case Report: A 70-year-old ma...

Background: Hirsutism is a common and disturbing complaint among women attending endocrine clinics. It is caused by androgen excess and when severe, might progress to virilization. Virilizing adrenal tumors are a rare cause of hirsutism.Case presentation: A 14 year old girl presented with primary amenorrhea, poor breast development (Tanner stage B1), hirsutism (Ferriman-gallwey score, FGS of 12/36) clitoromegaly (clitoral index >200 mm2). ...

Background: Insulin Autoimmune Syndrome is a rare condition characterized by hyperinsulinemic hypoglycemic episodes mediated by insulin autoantibodies (IAA). IAA form complexes with insulin leading to initial mild hyperglycemia and later hypoglycemia due to release of insulin. A comprehensive evaluation is necessary in all hyperinsulinemic hypoglycemia before a diagnosis of IAS is established. We present two cases of Hirata’s disease which presented with debilitating hypo...

Introduction: Graves’ disease is associated with mild hypercalcemia in about 1/5th of cases. T3, through its nuclear receptor activates osteoclasts resulting in accelerated bone turnover. Although mild hypercalcemia is common in Graves’ disease, symptomatic hypercalcemia is rare. We describe a case who presented with thyrotoxic storm and hypercalcemia.Case report: 52-year-old lady presented with thyrotoxic symptoms of weight loss, dysphagia for...